What is elucidating
Only about 30% to 50% of individuals have intestinal bacteria that produce equol. Konstantinopoulos PA, Kominea A, Vandoros G, et al.
While endogenous estrogenic hormones such as estradiol are steroids, equol is a nonsteroidal estrogen. Oestrogen receptor β (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour’s dedifferentiation.
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co.
Estrogen receptor α is found in endometrium, breast cancer cells, ovarian stroma cells, and the hypothalamus.
In the prostate, ERβ is highly expressed in the epithelial compartment, where it is the prevailing isoform.
5α-Androstane-3β,17β-diol (3β-Adiol) inhibits the migration of prostate cancer cell lines via ERβ activation. An alternate pathway for androgen regulation of brain function: activation of estrogen receptor β by the metabolite of dihydrotestosterone, 5α-androstane-3β,17β-diol.
This was accomplished by scaling the STZ volume with a log-linear fit to the strain rate, and also adjusting the activation energy of an STZ with a log-linear fit to maintain constant yield strength at differing strain rates.
Dehydroepiandrosterone (DHEA) binds to ERα and ERβ, with Ki values of 1.1 and 0.5 µM, respectively. 5α-Androstane-3β,17β-diol (3β-diol), an estrogenic metabolite of 5α-dihydrotestosterone, is a potent modulator of estrogen receptor ERβ expression in the ventral prostrate of adult rats. Estrogen receptors are overexpressed in approximately 70% of breast cancer cases, which is referred to as ER positive.While ERα promotes breast cell proliferation, ERβ inhibits proliferation and prevents breast cancer development via G2 cell cycle arrest.It may have beneficial effects on the incidence of prostate cancer and on physiological changes after menopause. Estrogen receptor–β activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFα mediated. After 3-month supplementation, the serum levels of sex hormone–binding globulin had significantly increased, while the serum levels of free testosterone and dihydrotestosterone had significantly decreased.